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Take it as soon as possible. This medicine should not be taken within four hours of colestipol or cholestyramine, as these medicines may reduce the absorption of hydrochlorothiazide from the gut. Some of the side effects that may occur while taking Microzide include black, tarry stools blood in urine or stools cough or hoarseness fever or chills joint pain lower back or side pain painful or difficult urination. If you have diabetes you should carefully monitor your blood sugar may be enhanced if you are or will be breast-feeding while you use Hydrochlorothiazide. Hydrochlorothiazide may cause you to become sunburned more easily. Hydrochlorothiazide can decrease the amount of potassium in the blood. Take Hydrochlorothiazide as directed, with meals, early in the day to avoid nocturia. If you experience bothersome side effects, stop taking Microzide and contact your doctor or local pharmacist. If you are also taking Hydrochlorothiazide along with diazoxide or a beta-blocker medicine.