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Esomeprazole reduce the production of acid in the stomach and intestines by blocking the enzyme in the wall of the stomach that produces acid. Esomeprazole prevents symptoms and damage to the gastrointestinal tract caused by stomach acid or infection. Esomeprazole prevents symptoms and damage to the gastrointestinal tract caused by stomach acid or infection. Decreasing stomach acid can help ulcers to heal and reflux, or heartburn symptoms to subside. There are no restrictions on food, beverages, or activities while taking Nexium, unless otherwise directed by your doctor. Nexium is a type of medicine known as an acid pump inhibitor which works by decreasing the acid produced by acid pumps. What should you watch for while taking Esomeprazole? There are no restrictions on food, beverages, or activities while taking Nexium, unless otherwise directed by your doctor.