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Use of Esomeprazole in pregnant women has not been appraised. Nexium is usually taken once a day at least one hour before a meal. What should you watch for while taking Esomeprazole? Nexium is usually taken once a day at least one hour before a meal. Nexium is usually taken once a day at least one hour before meals and at the same time every day. Esomeprazole provides improved acid control in patients with gastroesophageal reflux disease. Nexium capsules should be applied one hour before meals and at the same time every day.
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