Corticosteroids, including prednisone, are commonly used to suppress the immune system to attack by micro-organisms, it should be ensured that if antibiotics are required, that they are given in effective doses. Prednisone is inactive in the body and, in order to be effective, first must be converted to Prednisolone by enzymes in the liver. Since prednisone is used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly.
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